Stem cells show promise for rewiring the Parkinson’s brain
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New research suggests stem cell therapy could offer a more targeted approach to treating Parkinson’s disease by replacing the dopamine-producing neurons lost during its progression. In two small clinical trials recently published in the journal Nature, researchers transplanted stem cells directly into patients’ brains to restore these critical neurons. The treatment was well-tolerated, with no reported adverse effects. Early findings indicate that the transplanted cells may integrate into existing brain circuits and help rebuild the neural pathways disrupted by the disease.
Source
Tabar, V., Sarva, H., Lozano, A.M. et al. Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease. Nature 641, 978–983 (2025). https://doi.org/10.1038/s41586-025-08845-y
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