Limiting isoleucine boosts lifespan in mice
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A new study published in the journal Cell Metabolism found that restricting a single amino acid, isoleucine, significantly extended the lifespan of mice by up to 33%. The dietary change also improved metabolic health and resilience, suggesting that targeted nutrient restriction, rather than overall calorie reduction, could play a powerful role in promoting longevity and healthy aging. The researchers propose that similar isoleucine-limiting approaches in humans, whether through diet or pharmaceutical approaches, could potentially offer comparable anti-aging effects.
Source
Green CL, Trautman ME, Chaiyakul K, et al. Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice. Cell Metab. 2023;35(11):1976-1995.e6. doi:10.1016/j.cmet.2023.10.005
Additional Reading
https://www.sciencealert.com/cutting-back-on-one-amino-acid-increased-lifespan-of-mice-by-up-to-33