Folate vs. folic acid - why the source matters for men’s health

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Personalized vitamins promise better health, but new research highlights a surprising risk: men who take daily folic acid supplements may have a higher chance of developing prostate cancer. The key distinction is that folate, the natural form found in foods like leafy greens, appears to help prevent cancer- while folic acid, the synthetic version in many supplements, may increase risk. This is especially important because many assume folic acid supplements are a direct substitute for folate, when in fact they may have opposite effects.

Source

Figueiredo JC, Grau MV, Haile RW, Sandler RS, Summers RW, Bresalier RS, Burke CA, McKeown-Eyssen GE, Baron JA. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst. 2009 Mar 18;101(6):432-5. doi: 10.1093/jnci/djp019. Epub 2009 Mar 10. PMID: 19276452; PMCID: PMC2657096.

Additional Reading

https://www.theguardian.com/lifeandstyle/2022/aug/21/are-personalised-vitamins-key-good-health-supplements

https://www.hopkinsmedicine.org/health/wellness-and-prevention/is-there-really-any-benefit-to-multivitamins

https://www.ama-assn.org/delivering-care/public-health/what-doctors-wish-patients-knew-about-vitamins-and-supplements#:~:text=Tailor%20to%20your%20own%20body,modernized%20AMA's%20dietary%20supplement%20policy.

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