Metformin may help women live longer
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A recent study published in the Journals of Gerontology suggests that postmenopausal women with type 2 diabetes who began treatment with metformin had a 30% lower risk of dying before age 90 compared to those who took a different diabetes drug called sulfonylureas. The research which followed over 400 women for around 14–15 years, used a “target trial emulation” approach to estimate long-term outcomes. While the findings highlight metformin’s potential anti-aging benefits, researchers caution that the observational design means the results cannot prove causation.
Source
Aladdin H Shadyab, Mark A Espeland, Andrew O Odegaard, JoAnn E Manson, Bernhard Haring, Karen C Johnson, Zhao Chen, Bowei Zhang, Andrea Z LaCroix, Comparative Effectiveness of Metformin Versus Sulfonylureas on Exceptional Longevity in Women With Type 2 Diabetes: Target Trial Emulation, The Journals of Gerontology: Series A, Volume 80, Issue 7, July 2025, glaf095, https://doi.org/10.1093/gerona/glaf095
Additional Reading
https://www.sciencealert.com/common-diabetes-drug-linked-to-exceptional-longevity-in-women
https://www.health.harvard.edu/blog/is-metformin-a-wonder-drug-202109222605